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The Science Behind NAD+ Therapy: Boosting Energy, Brain Function, and Cellular Health

August 21, 2025

As interest in cellular health increases, NAD+ therapy is quickly becoming one of the most popular topics in the wellness field. NAD+, or nicotinamide adenine dinucleotide, is an essential coenzyme that promotes cellular repair, cognitive function, and a healthy metabolism. Our natural NAD+ stores unfortunately drop as we age, but we have some good news. We can replenish and maintain them using personalized intravenous (IV) therapies and treatments.

Why NAD+ Levels Naturally Decline

Smiling woman standing in front of a leafy green background, representing vitality and renewal through NAD+ therapy at Formula Wellness.
Woman With A Beautiful Smile by Mikhail Nilov is licensed with Pexels License

Most people experience a decline in their body’s natural supply of NAD+ in their 30s. Stress, poor diet, lack of sleep, and exposure to toxins can all accelerate this decline. Age, however, remains one of the biggest factors. As we age, our ability to produce NAD+ decreases. Chronic inflammation and oxidative stress, both of which are associated with aging, rapidly consume NAD+. While more research needs to be done to explore the broader implications of NAD+ depletion, some signs of low levels include:

Brain fog or memory loss

Sore or aching joints

Physical or mental fatigue

Poor sleep quality

Dull or lackluster skin

Mood swings

Inflammation

Sluggish metabolism

Low NAD+ levels are also linked to high blood pressure and several autoimmune diseases, such as psoriasis, inflammatory bowel disease, systemic lupus erythematosus, and gouty arthritis. 

How NAD+ Therapy Can Make You Look and Feel Your Best

Clients who restore their NAD+ levels through therapeutic injections notice a remarkable transformation in how they look, feel, and carry themselves. Research is still underway, but the potential physical and mental benefits are worth noting. The following are some of the most promising areas.

Restored Energy and Stamina

When NAD+ levels are low, even simple tasks can feel exhausting. That’s because NAD+ is responsible for creating adenosine triphosphate (ATP), the molecule responsible for producing cellular energy. As NAD+ levels drop, so does ATP, which can lead to fatigue and hinder recovery. You may experience a noticeable boost in energy after NAD+ therapy — and not the jittery, artificial kind that comes from drinking an extra cup of coffee. It’s a steadier feeling that mitigates chronic fatigue and age-related energy loss over time.

Clearer Thinking and Improved Mood

Some of the most common reasons to turn to NAD+ are to help with mental fog, concentration issues, and mood swings. After treatment, our clients often say they feel mentally sharper and more focused. This may be because NAD+ influences neurotransmitter activity and serotonin levels. Restoring and rebalancing serotonin has been shown to improve mood conditions, such as anxiety and depression, allowing patients to lead more vibrant lives. Early research also associates NAD+ supplementation with reduced neuroinflammation and improved synaptic function. 

Healthier Skin

After just a few NAD+ treatments, you may notice that your skin looks healthier and brighter. This is because NAD+ helps the body repair UV damage and lower oxidative stress. While NAD+ isn’t a replacement for a regular skincare program, routine injections can help you achieve a younger, more refreshed look. Some topical uses of NAD+ have also shown promise in treating psoriasis and other skin disorders.

Decreased Pain and Inflammation

As mentioned previously, low levels of NAD+ are associated with several chronic diseases and inflammation. Patients who are seeking pain relief without the use of harsh medications often turn to NAD+ injections to reduce joint discomfort. NAD+ therapy may offer support as part of a holistic pain management approach, aiding in faster recovery from physical strain and decreased systemic inflammation. This is because NAD+ appears to modulate inflammatory responses and may even help to regulate the activity of inflammatory cytokines.

Weight Management Support

NAD+ injections can also help if you are struggling to lose weight. When combined with healthy habits, NAD+ therapy supports mitochondrial function and increases metabolism. Some clients report they have more energy for workouts; others claim their cravings are more manageable, making it easier to stick to their health objectives and attain the results they’re aiming for.

Neurological Wellness and Addiction Recovery

NAD+ therapy is being studied to see if it could be beneficial in addiction recovery programs. It could help balance neurotransmitters while reducing withdrawal-related fatigue and brain fog. Due to these benefits, NAD+ therapy is also being examined more closely as a potential treatment for neurodegenerative conditions, such as Parkinson’s disease.

How Is NAD+ Administered?

There are several ways to enjoy the benefits of NAD+ supplementation. Each one comes with its advantages, making it easy to incorporate NAD+ therapy into holistic wellness plans.

NAD+ IV Infusions

NAD+ IV infusions are considered the gold standard because they’re delivered directly into the bloodstream for near-total absorption. At Formula Wellness, we combine NAD+ IV treatments with hydration fluids and B-complex vitamins to boost this process. We can also incorporate other nutrients to encourage cellular repair, mental clarity, and energy, depending on your goals and physiology.

NAD+ Injections

For a faster alternative, NAD+ injections deliver a concentrated dose into the muscle. This approach doesn’t provide you with the whole nutrient mix that infusions do, but it still packs a lot of power. Patients generally say that they feel more energetic and clear-headed within minutes of treatment. NAD+ injections are also a good way to keep up your health between full IV treatments.

NAD+ Oral Supplements

NAD+ capsules and powders are growing in popularity because they’re easy to take at home or on the go. Since oral NAD+ medications pass through the digestive tract, their absorption rate is less efficient than IVs or injections. Daily NAD+ capsules may be useful, however, to maintain baseline energy levels.

NAD+ Topical Products

NAD+ serums and creams are also popping up in the skincare industry. Early research suggests potential benefits, such as collagen support and cellular repair. Topical NAD+ products may also enhance skin tone and moisture. While promising, more clinical trials are required to prove their complete efficacy.

What To Expect During Your NAD+ Therapy Session

At Formula Wellness, we personalize the NAD+ therapy experience to achieve optimal results for each of our patients. Following an initial consultation, we carefully prepare the arm that will be used for IV therapy. Once the IV is placed, we start an infusion of hydrating fluids enriched with B-complex vitamins. The first bag usually takes about 30 minutes and primes the body for better NAD+ absorption. We’ll then move to a personalized NAD+ solution that is given gradually over two hours. This intentionally steady pace allows cells to absorb the coenzyme without discomfort. 

You may experience a gentle warming sensation or mild pressure during this part of the process, which is completely normal. Our dedicated staff monitors you closely to keep you comfortable. The entire visit usually lasts between two and a half to three hours, but we usually recommend that you clear your schedule so you can fully enjoy your restorative experience. We also offer NAD+ injections as a faster alternative for those with busy schedules, but these don’t include IV fluids or micronutrient support.

NAD+ Therapy FAQ

Before we wrap things up, our team at Formula Wellness has taken the time to answer some of the most common questions we receive about NAD+ therapy.

Is NAD+ Therapy Safe?

NAD+ is something the body already produces and uses every day. Because of this, treatments are generally well tolerated, but you may experience temporary side effects, such as nausea or brain fog. Mild muscle tension may also occur if the infusion runs too quickly. NAD+ supplements may interfere with some medications, such as insulin and antidepressants. At Formula Wellness, we schedule one-on-one individualized appointments to ensure you receive a treatment plan that is tailored to your specific requirements and goals. 

What Should I Do To Prepare for My Appointment?

We ask that you eat a nutritious meal and drink plenty of water before your NAD+ therapy appointment. Wear comfortable clothes and dress in light layers. Infusions usually take a couple of hours to complete, so feel free to bring a book or headphones for a more relaxing experience. 

How Can I Expect To Feel After NAD+ Therapy?

After their infusion, the majority of patients report feeling more focused and invigorated. You might experience mild fatigue, which is a typical side effect of NAD+ treatment. Although there is no need for downtime, benefits may be enhanced by drinking plenty of water. Within 24 hours, clients usually report feeling refreshed and revitalized. Consider regular follow-up sessions every two weeks to keep the benefits going. 

Schedule Your Consultation With Formula Wellness Today

Looking for a powerful way to support your energy levels and age gracefully? Have the Formula Wellness team create a tailored protocol specifically for you. By combining NAD+ with treatments such as IV nutrient therapy, hormone optimization, and personalized nutrition plans, we can help you build a sustainable foundation to support your long-term wellness. Schedule an appointment with us to get started.

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Our expert team is here to support you every step of the way. By collaborating with us, you’ll gain valuable insights, actionable plans, and the motivation you need to transform your health and well-being. Let’s take the first step together toward a healthier, happier you!

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